Hippocampal infusions of pyruvate reverse the memory-impairing effects of septal muscimol infusions
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چکیده
منابع مشابه
Increasing acetylcholine levels in the hippocampus or entorhinal cortex reverses the impairing effects of septal GABA receptor activation on spontaneous alternation.
Intra-septal infusions of the gamma-aminobutyric acid (GABA) agonist muscimol impair learning and memory in a variety of tasks. This experiment determined whether hippocampal or entorhinal infusions of the acetylcholinesterase inhibitor physostigmine would reverse such impairing effects on spontaneous alternation performance, a measure of spatial working memory. Male Sprague-Dawley rats were gi...
متن کاملThe memory-impairing effects of septal GABA receptor activation involve GABAergic septo-hippocampal projection neurons.
Septal infusions of the gamma-aminobutyric acid (GABA)(A) agonist muscimol impair memory, and the effect likely involves the hippocampus. GABA(A) receptors are present on the perikarya of cholinergic and GABAergic septo-hippocampal (SH) projections. The current experiments determined whether GABAergic SH projections are involved in the memory-impairing effects of septal GABA(A) receptor activat...
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It has been demonstrated that total parenteral nutrition (TPN) results in increased O2 consumption (VO2), CO2 production (VCO2) and minute ventilation (VE). TPN consists of a mixture of glucose and amino acids. The individual role of each of these nutrients in mediating these changes has not been well established. To examine the effects of the individual nutrients, continuous infusions of gluco...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2005
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2005.08.007